Mass Spectrometry Resource

Overview of Services

 

Mission:
The NIH/NIGMS-supported Biomedical Mass Spectrometry Core provides service, collaboration, training and advice on mass spectrometry-based analysis of biomolecules involved in metabolism, nutrition, obesity, diabetes, cancer and other pathophysiologic conditions.

The Core supports extensive research programs and mass spectrometry platforms for routine and custom-designed analyses focused on characterizing, identifying and quantifying lipids, carbohydrates, peptides, amino acids, many metabolic intermediates, and stable isotope labeled biomolecules found in in vitro and in vivo models.

Goals:

  • Establish collaborative research projects with basic and applied investigators at Washington University and other Institutions
  • Provide mass spectrometry-based analytical services
  • Educate and train students/fellows/junior faculty in the use and applications of mass spectrometry
  • Disseminate our research findings and inform the community about biomedical mass spectrometry

 

Leadership

 

Director: John Turk, MD, PhD; Professor of Medicine
Assistant Director: Fong-Fu Hsu, PhD; Research Professor of Medicine
Assistant Director: Kevin Yarasheski, PhD; Professor of Medicine
Staff Scientists: Jan Crowley, Robert Chott, Alan Bohrer, Haowei Song, PhD
Engineer: Robert Sanders
Administrative: Susan Schumacher


Location and hours of operation

 

Hours

 

Location

 8am-5pm
Monday - Friday
or by appointment      

8th Floor SouthWest Tower,
Washington University Medical School,
St. Louis, MO 63110

Links and Resources

  1. What is Mass Spectrometry? http://player.vimeo.com/video/68728880
  2. Our Web-site: http://msr.dom.wustl.edu
  3. National Institutes of Health http://www.nih.gov/
  4. National Institute of General Medical Sciences http://www.nigms.nih.gov/
  5. Washington Univ. Department of Chemistry http://www.chemistry.wustl.edu/
  6. Washington Univ. Division of Metabolism, Endocrinology and Lipid Research http://endo.wustl.edu/
  7. Washington Univ. Proteomics Laboratory http://proteomics.wustl.edu

Contacts

Name Role Phone Email Location
Susan Schumacher
General Core administration
 
314 362-2602
 
sschumac@wustl.edu
 

 
Robert Sanders
MS Hardware & Software
 
314 362-8190
 
rsanders@wustl.edu
 

 
Jan Crowley
Metabolites
 
314 362-7878
 
jcrowley@wustl.edu
 

 
Fong-Fu Hsu, PhD
Complex lipids/lipidomics
 
314 362-0056
 
fhsu@wustl.edu
 

 
Kevin Yarasheski, PhD
Metabolomics
 
314 362-8173
 
key@wustl.edu
 

 
John Turk, MD, PhD
Executive decisions
 
314 362-8190
 
jturk@wustl.edu
 

 

Services

Name Description
Consultation 

Experimental design/planning, appropriate control samples, interpreting mass spectra, sample preparation, acquiring authentic biomolecules and heavy isotope-labeled internal standards

 
Endogenous receptor ligands   
GC-APCI-quadrupole-time of flight MS methods  

(e.g., vitamins)

 
Glycerolipids   
Identifying/characterizing unknown or novel biomolecules, compounds, drugs   
Lipidomic, metabolomic, peptidomic profiling  

(untargeted, comparative)

 
Most central carbon metabolic-lipid intermediates   
Peptides   
Phospholipids   
Polyols   
Post-translationally modified peptides and proteins   
Prokaryotic biomolecules 

(e.g., bacteria)

 
Prostanoids   
Protein, lipid or metabolite flux measures using heavy isotope-labeled precursors  

(in vitro or in vivo)

 
Short and long chain fatty acyls   
Specialized Services 

MS instrument repairs, maintenance

 
Sphingolipids   
Sterol lipids   
Synthetic molecule/compound   
Training 

Instrument operation,  data analysis-processing-software, sample preparation, library/database searches for identifying candidate biomolecules

 

Service List


Search available services: View: by category alphabetically
Custom Designed Sample Analyses (7)
Other (3)
Routine Sample Analyses (10)